Whelan G, Flecknell P A
Comparative Biology Centre, University of Newcastle upon Tyne, Medical School, UK.
Lab Anim. 1994 Jan;28(1):70-7. doi: 10.1258/002367794781065735.
The results of a preliminary evaluation of etorphine/methotrimeprazine ('Small Animal Immobilon') and midazolam in rats and mice are reported, and this regimen is compared to fentanyl/fluanisone/midazolam in mice. In rats, a surgical plane of anaesthesia with good muscle relaxation was produced, but blood gas analysis showed the presence of severe hypoxia, hypercapnia and acidosis. In mice etorphine/methotrimeprazine/midazolam and fentanyl/fluanisone/midazolam produced adequate anaesthesia, but blood gas analysis showed severe respiratory depression with both regimens. Since etorphine/methotrimeprazine/midazolam produced severe respiratory depression in rats and mice it is suggested that this regimen is used with caution. Administration of supplemental oxygen would seem advisable when using either etorphine/methotrimeprazine/midazolam or fentanyl/fluanisone/midazolam in rats and mice.
报告了依托啡烷/甲氧异丁嗪（“小动物麻醉合剂”）和咪达唑仑在大鼠和小鼠中的初步评估结果，并将该方案与小鼠中的芬太尼/氟胺酮/咪达唑仑进行了比较。在大鼠中，产生了具有良好肌肉松弛的外科麻醉平面，但血气分析显示存在严重缺氧、高碳酸血症和酸中毒。在小鼠中，依托啡烷/甲氧异丁嗪/咪达唑仑和芬太尼/氟胺酮/咪达唑仑产生了足够的麻醉效果，但两种方案的血气分析均显示严重的呼吸抑制。由于依托啡烷/甲氧异丁嗪/咪达唑仑在大鼠和小鼠中产生严重的呼吸抑制，建议谨慎使用该方案。在大鼠和小鼠中使用依托啡烷/甲氧异丁嗪/咪达唑仑或芬太尼/氟胺酮/咪达唑仑时，补充氧气似乎是可取的。
