Perfumo F, Canepa A, Divino Filho J C, Nilsson E, Carrea A, Verrina E, Gusmano R, Bergström J
Nephrology Department, Istituto Giannina Gaslini, Genova, Italy.
Nephrol Dial Transplant. 1994;9(12):1778-85.
Nutritional status, assessed by anthropometric and biochemical methods, protein and amino-acid (AA) composition and muscle water were evaluated in 11 kidney transplanted children and in a control group of 10 children with normal renal function who were undergoing elective surgery. Samples of the rectus abdominis muscle were taken when surgery was performed in the control children and when the peritoneal catheter was removed in the transplanted children. The mean time from the transplantation to the study time was 97 +/- 14 days (range 72-114 days). Height was reduced in the transplanted children compared to the controls but skinfold thickness, arm muscle circumference and serum proteins (total protein, albumin, transferrin, pseudocholinesterase) were normal. The body mass index was over the 50 degree percentile in nine of the eleven children. The muscle contents of total, extracellular, and intracellular water, alkali-soluble protein (ASP), DNA and the ASP/DNA ratio were not significantly different in transplanted children from those in the controls. Plasma leucine and taurine levels were significantly decreased, whereas plasma citrulline and alanine levels and the glycine/serine ratio were increased. Muscle threonine, alanine+taurine, glycine and aspartic acid levels as well as the glycine/serine ratio were increased in the transplanted children. Transplanted children show an almost normal muscle AA profile and a plasma AA pattern that seems to be related to the prednisone therapy.
通过人体测量和生化方法评估营养状况，对11名肾移植儿童和10名接受择期手术的肾功能正常儿童对照组的蛋白质和氨基酸（AA）组成以及肌肉水分进行了评估。对照组儿童手术时以及移植儿童拔除腹膜导管时采集腹直肌样本。从移植到研究的平均时间为97±14天（范围72 - 114天）。与对照组相比，移植儿童身高降低，但皮褶厚度、上臂肌肉周长和血清蛋白（总蛋白、白蛋白、转铁蛋白、假性胆碱酯酶）正常。11名儿童中有9名体重指数超过第50百分位数。移植儿童肌肉中的总水分、细胞外水分、细胞内水分、碱溶性蛋白（ASP）、DNA以及ASP/DNA比值与对照组相比无显著差异。血浆亮氨酸和牛磺酸水平显著降低，而血浆瓜氨酸和丙氨酸水平以及甘氨酸/丝氨酸比值升高。移植儿童肌肉中的苏氨酸、丙氨酸 + 牛磺酸、甘氨酸和天冬氨酸水平以及甘氨酸/丝氨酸比值升高。移植儿童显示出几乎正常的肌肉氨基酸谱和似乎与泼尼松治疗有关的血浆氨基酸模式。
