Calvo C, Ruza F, Hernanz A, Madero R, Arroyo I, Delgado M A
Paediatric Intensive Care Unit, La Paz Children's Hospital, Madrid, Spain.
Clin Transplant. 1998 Oct;12(5):445-53.
We studied the evolution of plasma amino acid levels in children with chronic kidney failure after undergoing a renal transplantation. Plasma amino acid profile was studied in 10 children just before surgery, at admission in paediatric intensive care unit and 4, 8, 12, 24, 48 and 72 h after transplantation. Previous to the graft, plasma levels of glutamic acid (p < 0.01), hydroxyproline (p < 0.01), citrulline (p < 0.01) and arginine (p < 0.05) were significantly increased, whereas plasma levels of serine (p < 0.01), glutamine (p < 0.03), threonine (p < 0.01), tyrosine (p < 0.01), valine (p < 0.01), leucine (p < 0.01), tryptophan (p < 0.01), branched amino acids (BCAA) (p < 0.01), aromatic amino acids (AAA) (p < 0.01) and essential amino acids (EAA) (p < 0.01) were decreased in relation to control children. The amino acid profile evolution run parallel to the settle down of renal function parameters. Within 72 h after surgery, even before in some cases, all amino acids except tryptophan and arginine reached normal levels.
我们研究了慢性肾衰竭儿童肾移植后血浆氨基酸水平的变化。在10名儿童手术前、入住儿科重症监护病房时以及移植后4、8、12、24、48和72小时对其血浆氨基酸谱进行了研究。移植前，谷氨酸（p < 0.01）、羟脯氨酸（p < 0.01）、瓜氨酸（p < 0.01）和精氨酸（p < 0.05）的血浆水平显著升高，而丝氨酸（p < 0.01）、谷氨酰胺（p < 0.03）、苏氨酸（p < 0.01）、酪氨酸（p < 0.01）、缬氨酸（p < 0.01）、亮氨酸（p < 0.01）、色氨酸（p < 0.01）、支链氨基酸（BCAA）（p < 0.01）、芳香族氨基酸（AAA）（p < 0.01）和必需氨基酸（EAA）（p < 0.01）的血浆水平相对于对照儿童降低。氨基酸谱的变化与肾功能参数的稳定同步。术后72小时内，甚至在某些情况下更早，除色氨酸和精氨酸外的所有氨基酸均达到正常水平。
