Yoon Choi, Wook Yoon Young, Sik Na Heung, Ho Kim Sun, Mo Chung Jin
Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX 77555-0843 USA Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston, TX 77555-0843 USA Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, TX 77555-0843 USA.
Pain. 1994 Dec;59(3):369-376. doi: 10.1016/0304-3959(94)90023-X.
Previous studies by our laboratory established a rat model of neuropathic pain which displayed long-lasting heat hyperalgesia and mechanical allodynia that are sympathetically maintained. The present study was undertaken to extend our earlier findings by examining additional behavioral signs of ongoing pain and cold allodynia in our animal model and testing their sympathetic dependency. Neuropathic surgery was done by tightly ligating the L5 and L6 segmental spinal nerves of rats unilaterally. In addition to the behavioral signs of heat hyperalgesia and mechanical allodynia observed before, these rats displayed signs of ongoing pain (lasting at least 10 weeks) and cold allodynia (lasting at least 16 weeks). These behaviors were reduced markedly after surgical lumbar sympathectomy. The results of the present study, together with the previous study, suggest that our animal model exhibits neuropathic pain behaviors including ongoing pain, heat hyperalgesia, mechanical allodynia and cold allodynia. Since all of these behavioral signs are sympathetically maintained, our model represents a model for sympathetically maintained pain.
我们实验室之前的研究建立了一种神经性疼痛大鼠模型，该模型表现出持续的热痛觉过敏和机械性异常性疼痛，且这些症状由交感神经维持。本研究旨在通过检查我们动物模型中正在进行的疼痛和冷觉异常的其他行为体征，并测试它们对交感神经的依赖性，来扩展我们早期的研究结果。通过单侧紧密结扎大鼠的L5和L6节段性脊神经来进行神经病理性手术。除了之前观察到的热痛觉过敏和机械性异常性疼痛的行为体征外，这些大鼠还表现出持续疼痛（持续至少10周）和冷觉异常（持续至少16周）的体征。在进行腰交感神经切除术后，这些行为明显减轻。本研究结果与之前的研究一起表明，我们的动物模型表现出包括持续疼痛、热痛觉过敏、机械性异常性疼痛和冷觉异常在内的神经性疼痛行为。由于所有这些行为体征都由交感神经维持，我们的模型代表了一种交感神经维持性疼痛的模型。
