Chiaretti A, Piastra M, Castorina M, Tortorolo L, Valentini P, Polidori G
Istituto di Clinica Pediatrica, Università Cattolica del Sacro Cuore di Roma, Italia.
Pediatr Med Chir. 1994 Nov-Dec;16(6):585-6.
We report the case of a boy 5 years old we admitted to our PICU with signs of impending hepatic failure (hypertransaminasemia, hyperammonemia, prolonged PT) following mild upper respiratory infection and irrepressible vomiting. We observed no neurological abnormalities excepting slight lethargy; on the contrary, EEG findings showed severe diffuse slowing and high-voltage Delta activity. Our diagnosis of Reye's syndrome was later confirmed by liver biopsy. Clinical and electrophysiological signs recovered after 48-72 hours and no explication was found for this anomalous Reye's syndrome presentation. Further studies are needed for understanding the basis of neurological involvement of stage I Reye's syndrome.
我们报告了一名5岁男孩的病例，他因轻度上呼吸道感染和无法控制的呕吐后出现即将发生肝衰竭的迹象（高转氨酶血症、高氨血症、凝血酶原时间延长）而被收入我们的儿科重症监护病房（PICU）。除了轻微嗜睡外，我们未观察到神经学异常；相反，脑电图结果显示严重的弥漫性减慢和高电压δ活动。我们对瑞氏综合征的诊断后来通过肝活检得到证实。临床和电生理体征在48 - 72小时后恢复，且未找到这种异常瑞氏综合征表现的解释。需要进一步研究以了解I期瑞氏综合征神经受累的基础。
