Naderali E K, Poyser N L
Department of Pharmacology, University of Edinburgh Medical School, UK.
Prostaglandins Leukot Essent Fatty Acids. 1994 Dec;51(6):415-8. doi: 10.1016/0952-3278(94)90058-2.
Caffeine significantly (p < 0.05) increased the output of prostacyclin (PGI2) from the perfused rat mesenteric vascular bed. The outputs of PGE2 and PGF2 alpha were also increased by caffeine. This stimulatory response to caffeine did not show rapid desensitization. Ryanodine also increased PG output, suggesting that caffeine may be acting via the stimulation of a ryanodine receptor. The increased production of a vasodilator such as PGI2 from blood vessels following exposure to caffeine may explain why caffeine has a beneficial effect in angina.
咖啡因显著（p < 0.05）增加了灌注大鼠肠系膜血管床中前列环素（PGI2）的生成量。咖啡因还使前列腺素E2（PGE2）和前列腺素F2α（PGF2α）的生成量增加。这种对咖啡因的刺激反应并未表现出快速脱敏。ryanodine也增加了前列腺素的生成量，这表明咖啡因可能是通过刺激ryanodine受体起作用的。接触咖啡因后血管中诸如PGI2这种血管舒张剂生成量的增加，或许可以解释为什么咖啡因对心绞痛有有益作用。
