Ishida T, Dorfman H D
Department of Orthopaedic Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467-2490, USA.
Skeletal Radiol. 1995 Jan;24(1):47-51. doi: 10.1007/BF02425947.
Two cases of plasma cell myeloma in unusually young patients are reported. One was a case of multiple myeloma involving the skull and ribs in a 23-year-old woman, the other of solitary myeloma of the tibia in a 21-year-old man. Both the cases were non-secretory myeloma; however, monoclonal immunoglobulins were demonstrated by immunohistochemical studies. Plasma cell myeloma in patients below the age of 30 years is extremely rare. Our literature search disclosed 20 well-documented cases of multiple myeloma and 25 cases of solitary myeloma in patients at or below the age of 30. Plasma cell myeloma may occur in young persons, so it should be considered in the pre-biopsy differential diagnosis when bone lesions radiologically consistent with myeloma are encountered in young patients.
报告了两例异常年轻患者的浆细胞骨髓瘤病例。一例是一名23岁女性的多发性骨髓瘤，累及颅骨和肋骨；另一例是一名21岁男性的胫骨孤立性骨髓瘤。两例均为非分泌性骨髓瘤；然而，免疫组化研究证实存在单克隆免疫球蛋白。30岁以下患者的浆细胞骨髓瘤极为罕见。我们的文献检索发现了20例有充分记录的30岁及以下患者的多发性骨髓瘤病例和25例孤立性骨髓瘤病例。浆细胞骨髓瘤可能发生在年轻人中，因此当年轻患者出现放射学上与骨髓瘤相符的骨病变时，在活检前的鉴别诊断中应考虑到该病。
