Sahin A A, Myhre M, Ro J Y, Sneige N, Dekmezian R H, Ayala A G
Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Acta Cytol. 1991 May-Jun;35(3):277-80.
The case of a 63-year-old man with a previously undescribed morphologic variant of transitional cell carcinoma of the urinary bladder is reported. The patient initially presented with multiple lytic bony metastases of the ribs and skull. Aspiration biopsy of one of the lytic lesions of the skull showed tumor cells with a striking plasmacytoid appearance, similar to the plasma cells seen in myeloma, leading to an initial observer's diagnosis of multiple myeloma. Subsequently, a bladder tumor with the same cytomorphology was found; immunohistochemical and ultra structural studies performed on the aspirated material and on the bladder biopsy specimen clearly established the epithelial nature of this neoplasm.
报告了一例63岁男性患者，其患有膀胱移行细胞癌的一种此前未描述过的形态学变异型。患者最初表现为肋骨和颅骨的多发溶骨性骨转移。对颅骨一处溶骨性病变进行穿刺活检，结果显示肿瘤细胞具有显著的浆细胞样外观，类似于骨髓瘤中所见的浆细胞，这使得最初的观察者诊断为多发性骨髓瘤。随后，发现了具有相同细胞形态学特征的膀胱肿瘤；对穿刺材料和膀胱活检标本进行的免疫组织化学和超微结构研究明确证实了该肿瘤的上皮性质。
