Lithgow T, Glick B S, Schatz G
Biozentrum, University of Basel, Switzerland.
Trends Biochem Sci. 1995 Mar;20(3):98-101. doi: 10.1016/s0968-0004(00)88972-0.
Protein import into the mitochondria of Saccharomyces cerevisiae depends on two receptor subcomplexes composed of integral outer-membrane proteins. One subcomplex is the MAS37-MAS70 heterodimer, which preferentially recognizes the mature regions of precursor proteins associated with ATP-dependent cytosolic chaperones. The other subcomplex contains the acidic proteins MAS20 and MAS22, which recognize the positively charged targeting sequences of a wide variety of mitochondrial precursors. We propose that the two subcomplexes can act together as a single, multifunctional receptor that binds simultaneously to different regions of a precursor molecule.
蛋白质导入酿酒酵母线粒体依赖于由线粒体外膜整合蛋白组成的两个受体亚复合物。一个亚复合物是MAS37-MAS70异二聚体，它优先识别与ATP依赖的胞质伴侣蛋白相关的前体蛋白的成熟区域。另一个亚复合物包含酸性蛋白MAS20和MAS22，它们识别多种线粒体前体的带正电荷的靶向序列。我们提出，这两个亚复合物可以作为一个单一的多功能受体共同发挥作用，同时结合前体分子的不同区域。
