Palmer J R, Rosenberg L, Rao R S, Shapiro S
Slone Epidemiology Unit, School of Public Health, Boston University School of Medicine, Brookline, MA 02146, USA.
Am J Epidemiol. 1995 Apr 15;141(8):724-31. doi: 10.1093/oxfordjournals.aje.a117494.
Whether coffee consumption increases the risk of coronary heart disease has not yet been established. In a case-control study of nonfatal myocardial infarction among Massachusetts women aged 45-69 years in 1986-1990, 858 cases with first infarctions were compared with 858 community controls matched on age and town precinct. Detailed information on coffee drinking, cigarette smoking, and other factors was obtained by telephone interview. Relative risks (as estimated by odds ratios) and their 95% confidence intervals were computed from multiple logistic regression analyses that controlled for smoking and other risk factors. The risk of myocardial infarction increased with increasing number of cups per day among both drinkers of any type of coffee and drinkers of caffeine-containing coffee only: tests for trend, p = 0.002 and p = 0.0004, respectively. For consumption of caffeine-containing coffee alone, the relative risk estimates for 5-6 cups, 7-9 cups, and 10 or more cups per day relative to less than 1 cup per day were 1.4 (95% confidence interval (CI) 0.8-2.5), 2.1 (95% CI 0.9-4.9), and 2.5 (95% CI 1.0-6.5), respectively. No increase was observed for fewer than 5 cups per day. The positive association with heavy coffee drinking was present among nonsmokers as well as smokers. These findings and other recent studies suggest that heavy coffee consumption increases the risk of myocardial infarction.
喝咖啡是否会增加冠心病风险尚未确定。在一项针对1986年至1990年间马萨诸塞州45至69岁女性非致命性心肌梗死的病例对照研究中，858例首次发生梗死的病例与858名按年龄和城镇选区匹配的社区对照进行了比较。通过电话访谈获取了有关咖啡饮用、吸烟及其他因素的详细信息。相对风险（以比值比估计）及其95%置信区间通过对吸烟和其他风险因素进行控制的多元逻辑回归分析计算得出。无论是饮用任何类型咖啡的人群还是仅饮用含咖啡因咖啡的人群，心肌梗死风险均随每日杯数增加而上升：趋势检验中，p值分别为0.002和0.0004。仅就含咖啡因咖啡的饮用而言，相对于每日饮用不足1杯，每日饮用5至6杯、7至9杯以及10杯及以上的相对风险估计值分别为1.4（95%置信区间（CI）0.8 - 2.5）、2.1（95% CI 0.9 - 4.9）和2.5（95% CI 1.0 - 6.5）。每日饮用少于5杯未观察到风险增加。重度咖啡饮用与心肌梗死的正相关关系在不吸烟者和吸烟者中均存在。这些发现及其他近期研究表明，大量饮用咖啡会增加心肌梗死风险。
