Rosenberg L, Slone D, Shapiro S, Kaufman D W, Stolley P D, Miettinen O S
Am J Epidemiol. 1980 Jun;111(6):675-81. doi: 10.1093/oxfordjournals.aje.a112945.
The effect of consumption of caffeine-containing coffee on the risk of myocardial infarction in women 30-49 years of age was investigated. In this study 487 patients with first infarctions were compared with 980 controls whose admissions were for acute emergencies. Overall and in various subgroups, coffee drinking and myocardial infarction were weakly and not significantly associated: the overall estimated relative risk for women drinking at least five cups daily, compared with women drinking none, was 1.4 after control for all identified potential confounding factors (95% confidence interval, 1.0-1.9). Also, the frequency of coffee drinking was greater among controls, whose admissions were for acute emergencies, than among other patients without myocardial infarction, most of whom had been admitted for chronic conditions. If patients of the latter type tend to avoid coffee, then their inclusion in the control series of previous hospital-based studies may have led to overestimation of the magnitude of the association between coffee and myocardial infarction.
研究了饮用含咖啡因咖啡对30至49岁女性心肌梗死风险的影响。在本研究中，将487例首次发生心肌梗死的患者与980例因急性紧急情况入院的对照者进行了比较。总体而言，在各个亚组中，喝咖啡与心肌梗死之间的关联较弱且无显著意义：在控制了所有已确定的潜在混杂因素后，与不喝咖啡的女性相比，每天至少饮用五杯咖啡的女性的总体估计相对风险为1.4（95%置信区间为1.0 - 1.9）。此外，因急性紧急情况入院的对照者喝咖啡的频率高于其他无心肌梗死的患者，后者大多数因慢性病入院。如果后一种类型的患者倾向于避免喝咖啡，那么将他们纳入以往基于医院的研究的对照组可能导致高估咖啡与心肌梗死之间关联的强度。
