Purvin V A
Midwest Eye Institute, Methodist Hospital of Indiana, Indianapolis, USA.
Arch Ophthalmol. 1995 Apr;113(4):482-4. doi: 10.1001/archopht.1995.01100040102034.
To identify a distinctive constellation of persistent visual abnormalities secondary to treatment with clomiphene citrate.
Description of the clinical findings in three patients with visual disturbance secondary to clomiphene treatment.
A neuro-ophthalmology referral center.
Three women aged 32 to 36 years treated for infertility with clomiphene for 4 to 15 months.
All three patients experienced prolonged afterimages (palinopsia), shimmering of the peripheral field, and photophobia while undergoing treatment with clomiphene. The results of the neuro-ophthalmologic examination and electrophysiologic studies were normal in all three patients. Unlike previously reported cases, visual symptoms did not resolve on cessation of treatment. Patients remain symptomatic from 2 to 7 years after discontinuing treatment with the medication.
Treatment with clomiphene can cause prolonged visual disturbance. Patients who develop such symptoms should be advised that continued administration may cause irreversible changes. Women with characteristic visual symptoms should be questioned about past use of clomiphene.
确定克罗米芬治疗后出现的一系列独特的持续性视觉异常。
描述3例克罗米芬治疗继发视觉障碍患者的临床发现。
神经眼科转诊中心。
3名年龄在32至36岁的女性，使用克罗米芬治疗不孕症4至15个月。
所有3例患者在使用克罗米芬治疗期间均出现长时间后像（持久性视觉残留）、周边视野闪烁和畏光。所有3例患者的神经眼科检查和电生理研究结果均正常。与先前报道的病例不同，停药后视觉症状并未缓解。停药2至7年后患者仍有症状。
克罗米芬治疗可导致持续性视觉障碍。出现此类症状的患者应被告知继续用药可能会导致不可逆的变化。有典型视觉症状的女性应询问其过去是否使用过克罗米芬。
