Iantomasi T, Marraccini P, Favilli F, Vincenzini M T, Ferretti P, Tonelli F
Dipartimento di Scienze Biochimiche, Università di Firenze, Italia.
Biochem Med Metab Biol. 1994 Dec;53(2):87-91. doi: 10.1006/bmmb.1994.1062.
A statistically significant decrease of glutathione (GSH) and an increase of GSH disulfide (GSSG) both in healthy and ill ileum of patients with Crohn's disease in comparison with the controls (without this pathology) is demonstrated. However, the lowering of these levels was more remarkable in ill ileum in which high levels of GSSG were detected, too. These alterations may be in part explained by the changes obtained in GSH-related enzyme levels. Finally, considering the results that others and we obtained by studies on GSH oral absorption in rat intestine, an oral therapy of GSH in Crohn's disease is suggested.
与对照组（无此病）相比，克罗恩病患者的健康回肠和患病回肠中谷胱甘肽（GSH）均有统计学显著下降，二硫化谷胱甘肽（GSSG）均有增加。然而，这些水平的降低在检测到高水平GSSG的患病回肠中更为显著。这些改变部分可能由GSH相关酶水平的变化来解释。最后，考虑到我们和其他人通过对大鼠肠道中GSH口服吸收的研究获得的结果，建议对克罗恩病进行GSH口服治疗。
