验证肠道通透性方法以预测人和大鼠口服剂量的吸收分数。 - Suppr

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超能文献

The validation of the intestinal permeability approach to predict oral fraction of dose absorbed in humans and rats.

作者信息

Chiou W L

机构信息

Department of Pharmaceutics and Pharmacodynamics, College of Pharmacy, University of Illinois at Chicago 60612, USA.

出版信息

Biopharm Drug Dispos. 1995 Jan;16(1):71-5. doi: 10.1002/bdd.2510160107.

DOI:10.1002/bdd.2510160107

PMID:7711284

Abstract

摘要

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The validation of the intestinal permeability approach to predict oral fraction of dose absorbed in humans and rats.验证肠道通透性方法以预测人和大鼠口服剂量的吸收分数。

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引用本文的文献

Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.为何利用大鼠模型预测人体肠道药物吸收和口服生物利用度具有挑战性？

Pharm Res. 2006 Aug;23(8):1675-86. doi: 10.1007/s11095-006-9041-2.

The rate and extent of oral bioavailability versus the rate and extent of oral absorption: clarification and recommendation of terminology.口服生物利用度的速率和程度与口服吸收的速率和程度：术语的澄清与建议

J Pharmacokinet Pharmacodyn. 2001 Feb;28(1):3-6. doi: 10.1023/a:1011544501243.

Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats.64种药物在人体和大鼠体内口服剂量吸收分数的线性相关性。

Pharm Res. 1998 Nov;15(11):1792-5. doi: 10.1023/a:1011981317451.

New perspectives on the theory of permeability and resistance in the study of drug transport and absorption.药物转运与吸收研究中通透性和阻力理论的新视角

J Pharmacokinet Biopharm. 1996 Aug;24(4):433-42. doi: 10.1007/BF02353521.

We may not measure the correct intestinal wall permeability coefficient of drugs: alternative absorptive clearance concept.我们可能无法测量药物正确的肠壁渗透系数：替代性吸收清除概念。

J Pharmacokinet Biopharm. 1995 Jun;23(3):323-31. doi: 10.1007/BF02354288.

First-pass accumulation of salicylic acid in gut tissue after absorption in anesthetized rat.麻醉大鼠吸收后水杨酸在肠道组织中的首过蓄积

Pharm Res. 1995 Sep;12(9):1323-7. doi: 10.1023/a:1016273623737.

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