Forster P L, Schoenfeld F B, Marmar C R, Lang A J
University of California, San Francisco.
J Trauma Stress. 1995 Jan;8(1):143-9. doi: 10.1007/BF02105412.
Irritability is often a problem for patients with Post-Traumatic Stress Disorder (PTSD). We describe two cases that illustrate the use of lithium in the treatment of veterans with PTSD who complained of serious problems with irritability or angry outbursts. These cases are discussed in the context of evidence that lithium may be useful in other patients with disorders of impulse control. The evidence linking disorders of anger and impulse control to a dysregulation in neurotransmitter regulation, particularly in serotonergic pathways, supports a psychopharmacologic approach to treatment. These findings should lead to further study of the role of lithium in the treatment of this symptom complex in patients with PTSD.
易怒常常是创伤后应激障碍（PTSD）患者面临的一个问题。我们描述了两例病例，用以说明锂盐在治疗抱怨存在严重易怒或愤怒爆发问题的退伍军人PTSD患者中的应用。这些病例是在锂盐可能对其他冲动控制障碍患者有用的证据背景下进行讨论的。将愤怒和冲动控制障碍与神经递质调节失调（特别是血清素能通路）相联系的证据，支持了一种药物治疗方法。这些发现应促使人们进一步研究锂盐在治疗PTSD患者这一症状群中的作用。
