Dozier S E, Diven D G, Jones D, Brysk M, Sanchez R L, Motamedi M
Department of Dermatology, University of Texas Medical Branch, Galveston, USA.
Dermatol Surg. 1995 Mar;21(3):237-40. doi: 10.1111/j.1524-4725.1995.tb00161.x.
Developmental work in tattoo removal is currently carried out in animal models whose skin has different optical and mechanical properties from human skin.
To observe laser effects on tattoos in a new human skin model and that of in vivo guinea pig skin.
A comparison of the efficacy of the Q-switched Alexandrite laser (750 nm, 100-120 nanoseconds) in tattooed harvested human skin and guinea pig skin was performed. Visual assessments as well as histologic and electron microscopy evaluation before and after treatment are reported.
Mild to moderate clearing of black tattoo pigment, as judged by visual assessment, was found after one laser treatment in both the in vitro human skin model and guinea pig skin. Blue and green ink showed similar results to black ink in human skin whereas red and yellow ink did not respond in our model.
Possible mechanisms of tattoo lightening and the usefulness of the in vitro human skin model are discussed.
目前纹身去除的研发工作是在动物模型中开展的，这些动物的皮肤在光学和机械特性方面与人类皮肤不同。
观察新型人体皮肤模型及豚鼠活体皮肤中激光对纹身的作用。
对调Q紫翠宝石激光（750纳米，100 - 120纳秒）在取自人体的纹身皮肤和豚鼠皮肤中的疗效进行比较。报告了治疗前后的视觉评估以及组织学和电子显微镜评估结果。
通过视觉评估判断，在体外人体皮肤模型和豚鼠皮肤中，单次激光治疗后黑色纹身色素出现轻度至中度清除。在人体皮肤中，蓝色和绿色墨水的结果与黑色墨水相似，而红色和黄色墨水在我们的模型中无反应。
讨论了纹身变淡的可能机制以及体外人体皮肤模型的实用性。
