旨在抑制CD4与HIV GP120结合的拟肽拮抗剂。
Peptidomimetic antagonists designed to inhibit the binding of CD4 to HIV GP120.
作者信息
Ramurthy S, Lee M S, Nakanishi H, Shen R, Kahn M
机构信息
Department of Pathobiology, University of Washington, Seattle 98195.
出版信息
Bioorg Med Chem. 1994 Sep;2(9):1007-13. doi: 10.1016/s0968-0896(00)82049-0.
PMID:7712121
Abstract
Attempts to enhance the efficacy of our previously reported CD4 CDR2-like (residues 40-45) mimetic 1 by incorporation of the critical guanidine residue Arg-59 of CD4 are described.
摘要
本文描述了通过引入CD4关键的胍基残基Arg-59来提高我们之前报道的CD4 CDR2样（40-45位残基）模拟物1的功效的尝试。
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