在白蛋白存在的情况下，苏拉明阻断CD4与糖蛋白120结合的能力会逆转。
The ability of suramin to block CD4-gp120 binding is reversed in the presence of albumin.
作者信息
Yao X J, Wainberg M A, Richard M, Pollak M
机构信息
Lady Davis Institute, Jewish General Hospital, Cote-Ste-Catherine, Canada.
出版信息
Antimicrob Agents Chemother. 1991 Dec;35(12):2636-8. doi: 10.1128/AAC.35.12.2636.
Abstract
We have shown that suramin can directly inhibit the binding of the human immunodeficiency virus type 1 gp120 envelope protein to immobilized CD4, thus helping to explain the previously described antiviral properties of suramin. However, physiological concentrations of serum albumin significantly attenuated suramin's antiviral effects, suggesting that only free suramin has antiviral properties. Reported discrepancies between in vitro and clinical activities of suramin may be due to differences between free suramin levels in experimental assays and those achievable clinically.
摘要
我们已经表明，苏拉明可以直接抑制人类免疫缺陷病毒1型gp120包膜蛋白与固定化CD4的结合，从而有助于解释先前所述的苏拉明的抗病毒特性。然而，生理浓度的血清白蛋白显著减弱了苏拉明的抗病毒作用，这表明只有游离的苏拉明具有抗病毒特性。苏拉明体外活性和临床活性之间报道的差异可能是由于实验测定中的游离苏拉明水平与临床可达到的水平之间的差异所致。
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