异嗜铬酮类似物对gp120-CD4结合的合成及抑制活性
Synthesis and inhibitory activities of isochromophilone analogues against gp120-CD4 binding.
作者信息
Sun X L, Takayanagi H, Matsuzaki K, Tanaka H, Furuhata K, Omura S
机构信息
School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1996 Jul;49(7):689-92. doi: 10.7164/antibiotics.49.689.
PMID:8784432
Abstract
Several isochromophilone analogues were synthesized from sclerotiorin (1) by Wittig reactions and aldol condensation reaction. The structures of the products were elucidated from MS, elemental analysis, 1H NMR and 13C NMR spectra, and their inhibitory activities against gp120-CD4 binding were determined.
摘要
通过维蒂希反应和羟醛缩合反应，从硬葡菌素（1）合成了几种异嗜菌素类似物。通过质谱、元素分析、1H核磁共振和13C核磁共振光谱对产物的结构进行了阐明，并测定了它们对gp120-CD4结合的抑制活性。
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