Cassady J R
Department of Radiation Oncology, University of Arizona Health Sciences Center, Tucson 85724, USA.
Int J Radiat Oncol Biol Phys. 1995 Mar 30;31(5):1249-56. doi: 10.1016/0360-3016(94)00428-N.
An analysis of the normal tissue effects of irradiation of the kidney is presented. Various clinical syndromes resulting from treatment are described as well as the potential cellular basis for these findings. Effects of concurrent and/or sequential treatment with irradiation and various chemotherapeutic agents are discussed and the impact of these agents on toxicity presented. Adverse consequences of renal treatment in the child is described and possible radiation effects on so-called compensatory hypertrophy following nephrectomy presented. Renal consequences described to date of bone marrow transplantation programs utilizing irradiation are also presented. The necessity of a dose-volume histogram analysis approach to analyzing renal toxic effects in patients followed for long (> 10 year) periods is essential in developing accurate guidelines of renal tolerance.
本文对肾脏照射的正常组织效应进行了分析。描述了治疗导致的各种临床综合征以及这些发现的潜在细胞基础。讨论了放疗与各种化疗药物同时和/或序贯治疗的效果，并介绍了这些药物对毒性的影响。描述了儿童肾脏治疗的不良后果，并介绍了肾切除术后所谓代偿性肥大可能受到的辐射影响。还介绍了利用放疗的骨髓移植项目迄今为止的肾脏后果。在制定准确的肾脏耐受性指南时，采用剂量-体积直方图分析方法来分析长期（>10年）随访患者的肾脏毒性效应至关重要。
