Batcik Sule, Tumkaya Levent, Dil Eyup, Kazancioglu Leyla, Gaygusuz Elif, Yazici Zihni Acar, Ozden Zulkar, Kilinc Kagan, Mercantepe Tolga
Department of Anesthesiology and Reanimation, Faculty of Medicine, Recep Tayyip Erdogan University, 53100 Rize, Turkey.
Department of Histology and Embryology, Faculty of Medicine, On Dokuz Mayis University, 55010 Samsun, Turkey.
Life (Basel). 2025 May 31;15(6):897. doi: 10.3390/life15060897.
: Approximately 18 million individuals were diagnosed with cancer in 2018. The rate is predicted to exceed 22 million by 2030. Radiotherapy is an essential part of cancer therapy, with well documented local and systemic side effects, including oxidative stress and apoptosis. Kidney tissues are also exposed to the deleterious effects of radiotherapy, resulting in acute or chronic kidney function impairment. This study compared the effects of the potent selective α2-adrenoreceptor agonist dexmedetomidine and amifostine on oxidative stress and apoptosis in kidney damage induced by x-irradiation in rats. : Forty Sprague Dawley rats were assigned into five groups: control, x-irradiation, x-irradiation + amifostine, x-irradiation + dexmedetomidine 100 µg/kg, and X-ray irradiation + dexmedetomidine 200 µg/kg. : Necrotic tubules and degenerative Bowman's capsules were present in the x-irradiation group. An increase was determined in malondialdehyde (MDA), Cleaved Caspase-3, and 8-OHdG levels compared to the control group ( ≤ 0.05). In contrast, there was a decrease in necrotic tubules, degenerative Bowman's capsules, and the levels of MDA, Cleaved Caspase-3, and 8-OHdG in the amifostine and dexmedetomidine 100 µg/kg and 200 µg/kg treatment groups ( ≤ 0.05). : Alpha 2 adrenergic receptor agonists exhibit protective effects against kidney injury induced in association with x-irradiation by reducing oxidative stress and apoptosis.
2018年约有1800万人被诊断患有癌症。预计到2030年这一数字将超过2200万。放射治疗是癌症治疗的重要组成部分，其局部和全身副作用已得到充分记录，包括氧化应激和细胞凋亡。肾脏组织也会受到放射治疗的有害影响，导致急性或慢性肾功能损害。本研究比较了强效选择性α2 - 肾上腺素能受体激动剂右美托咪定和氨磷汀对大鼠X线照射所致肾损伤中氧化应激和细胞凋亡的影响。40只Sprague Dawley大鼠被分为五组：对照组、X线照射组、X线照射 + 氨磷汀组、X线照射 + 100 μg/kg右美托咪定组和X线照射 + 200 μg/kg右美托咪定组。X线照射组出现肾小管坏死和鲍曼囊退变。与对照组相比，丙二醛（MDA）、裂解的半胱天冬酶 - 3和8 - 羟基脱氧鸟苷（8 - OHdG）水平升高（P≤0.05）。相比之下，氨磷汀组以及100 μg/kg和200 μg/kg右美托咪定治疗组的肾小管坏死、鲍曼囊退变以及MDA、裂解的半胱天冬酶 - 3和8 - OHdG水平均降低（P≤0.05）。α2肾上腺素能受体激动剂通过减轻氧化应激和细胞凋亡，对X线照射所致肾损伤具有保护作用。
