惊恐障碍患者中恐惧症状作为药物治疗无反应的预测因素（初步报告）

Phobic symptoms as predictors of nonresponse to drug therapy in panic disorder patients (a preliminary report).

作者信息

Slaap B R, van Vliet I M, Westenberg H G, den Boer J A

机构信息

Department of Psychiatry, Rudolf Magnus Institute for Neuroscience, Academic Hospital Utrecht, The Netherlands.

出版信息

J Affect Disord. 1995 Jan 11;33(1):31-8. doi: 10.1016/0165-0327(94)00070-p.

DOI:10.1016/0165-0327(94)00070-p

PMID:7714306

Abstract

Factors that predict nonresponse to drug therapy (brofaromine or fluvoxamine) were investigated in a sample of 44 panic disorder patients. We used a strict definition of nonresponse to find patients who did not respond at all after 12 weeks of treatment. Using this definition, 15 patients (32.6%) were considered nonresponders. Nonresponders had a higher score on the Blood-Injury subscore of the Fear Questionnaire (FQ) and more often had high scores on several FQ subscores, indicative of comorbid phobic symptoms. These variables were subsequently used to predict nonresponse.

摘要

在44名惊恐障碍患者样本中，对预测药物治疗（溴法罗明或氟伏沙明）无反应的因素进行了研究。我们采用了严格的无反应定义，以找出在12周治疗后完全没有反应的患者。根据这个定义，15名患者（32.6%）被视为无反应者。无反应者在恐惧问卷（FQ）的血液-损伤子量表上得分更高，并且在几个FQ子量表上经常有高分，这表明存在共病恐惧症状。这些变量随后被用于预测无反应情况。