Slaap B R, van Vliet I M, Westenberg H G, Den Boer J A
Department of Biological Psychiatry, Academic Hospital Groningen, Netherlands.
Psychopharmacology (Berl). 1996 Oct;127(4):353-8. doi: 10.1007/s002130050097.
Little is known about biological predictors of treatment response in panic disorder (PD). In the present study heart rate, blood pressure, plasma cortisol and plasma MHPG were investigated at baseline in a sample of 44 PD patients as possible predictors for nonresponse to treatment. We used a strict definition of nonresponse to find patients who did not respond at all after 12 weeks of treatment with brofaromine or fluvoxamine. Patients were considered nonresponders when they fulfilled two criteria: they did not show a 50% reduction of agoraphobic avoidance and they still experienced panic attacks at endpoint. The variables that differed significantly between the groups were used to predict nonresponse to drug therapy. Using this strict definition of nonresponse, 15 patients (32.6%) were considered nonresponders. These patients were characterised by a higher plasma MHPG concentration and a higher heart rate at baseline. These variables were subsequently used to predict nonresponse.
关于惊恐障碍（PD）治疗反应的生物学预测因素，人们知之甚少。在本研究中，对44名PD患者样本在基线时的心率、血压、血浆皮质醇和血浆3-甲氧基-4-羟基苯乙二醇（MHPG）进行了调查，将其作为治疗无反应的可能预测因素。我们采用了严格的无反应定义来找出在接受溴法罗明或氟伏沙明治疗12周后完全没有反应的患者。当患者满足两个标准时被视为无反应者：他们的广场恐怖回避没有减少50%，并且在终点时仍经历惊恐发作。两组之间有显著差异的变量被用于预测药物治疗的无反应。采用这种严格的无反应定义，15名患者（32.6%）被视为无反应者。这些患者的特征是基线时血浆MHPG浓度较高和心率较高。随后使用这些变量来预测无反应。
