A recommended revision in the RTOG thermometry guidelines for hyperthermia administered by ultrasound.

RTOG thermometry guidelines for clinical trials of hyperthermia using planar ultrasound recommended that temperatures be mapped in polyurethane catheters by use of single-junction copper-constantan thermocouples. These guidelines were based on an assumption that the error in temperature measurement due to thermal conduction would generally not exceed +/- 0.3 degrees C. The validity of this assumption was tested with a commercially available single-junction copper-constantan thermocouple. The width of the point spread function, an indicator of the relative magnitude of the conduction error, was five times greater than expected. As a result, the conduction error is projected to exceed 0.3 degrees C in a temperature gradient of only 1.5 degrees C/cm. This projection was confirmed by mapping a thermal peak which simulates a typical clinical temperature profile. This peak had an amplitude of 6 degrees C, a full-width at half-maximum of 3.5 cm, and a maximum gradient of approximately 3 degrees C/cm. Temperatures measured at 0.5-cm intervals over the span of this peak were in error by a mean of +/- 0.6 degrees C. It is strongly recommended that the RTOG guidelines be revised to replace copper-constantan thermocouples with manganin-constantan single- or multi-junction thermocouples which will assure that the conduction error will be < +/- 0.3 degrees C.