Wilmes L J, Hoehn-Berlage M, Els T, Bockhorst K, Eis M, Bonnekoh P, Hossmann K A
Max-Planck-Institut für Neurologische Forschung, Abteilung für Experimentelle Neurologie, Köln, Germany.
J Magn Reson Imaging. 1993 Jan-Feb;3(1):5-12. doi: 10.1002/jmri.1880030103.
T1 and T2 were determined simultaneously in vivo at 4.7 T in implanted rat brain tumors. Three different tumor cell lines were implanted in the right caudate nucleus: the F98 glioma, the E367 neuroblastoma, and the RN6 schwannoma. Their T1 and T2 values (mean +/- standard deviation [msec]), respectively, were 1,312 +/- 107 and 89 +/- 3 (glioma), 1,284 +/- 86 and 87 +/- 7 (neuroblastoma), and 1,338 +/- 85 and 86 +/- 9 (schwannoma). The T1 values (msec) of normal brain and muscle were 1,090 +/- 59 and 1,139 +/- 77, respectively, and the T2 values (msec) were 76 +/- 3 and 36 +/- 2, respectively. After injection of the contrast agent manganese (III) tetraphenylporphine sulfonate (TPPS) the T1 of all three tumors decreased by 30% and the T2 by 10%, whereas no such change in relaxivity was noted in normal brain. As a result, strong contrast enhancement of the three tumor types was seen on T1-weighted images. The tumor was clearly delineated and correlated with findings at histologic examination. This tumor enhancement was followed up for 4 days with quantitative relaxation time measurements, and the strong, selective reduction in T1 for all three tumor types after Mn-TPPS injection was preserved over the entire observation period.
在植入大鼠脑肿瘤的情况下，于4.7 T场强下在体同时测定T1和T2值。将三种不同的肿瘤细胞系植入右侧尾状核：F98胶质瘤、E367神经母细胞瘤和RN6雪旺氏细胞瘤。它们的T1和T2值（平均值±标准差 [毫秒]）分别为：1312±107和89±3（胶质瘤）、1284±86和87±7（神经母细胞瘤）以及1338±85和86±9（雪旺氏细胞瘤）。正常脑和肌肉的T1值（毫秒）分别为1090±59和1139±77，T2值（毫秒）分别为76±3和36±2。注射造影剂四苯基卟啉磺酸锰（III）（TPPS）后，所有三种肿瘤的T1降低30%，T2降低10%，而正常脑中未观察到弛豫率的此类变化。结果，在T1加权图像上可见三种肿瘤类型均有明显的对比增强。肿瘤被清晰勾勒，且与组织学检查结果相符。通过定量弛豫时间测量对这种肿瘤增强进行了4天的随访，在整个观察期内，注射Mn-TPPS后所有三种肿瘤类型的T1均出现强烈的选择性降低。
