Sassler A M, McClatchey K D, Wolf G T, Fisher S G
Department of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, USA.
Laryngoscope. 1995 Apr;105(4 Pt 1):413-6. doi: 10.1288/00005537-199504000-00014.
Tumor-associated tissue eosinophilia (TATE) has been related to prognosis in epithelial cancers, including cancers at several head and neck sites. This study prospectively examined 248 patients with stage III and IV laryngeal squamous cell carcinoma to determine prevalence and potential prognostic significance of TATE. Pretreatment tumor specimens were histopathologically evaluated. Presence and degree of TATE were analyzed with regard to other tumor characteristics, patient characteristics, and outcome criteria. Median follow-up was 48 months. Eosinophilia was found in 22.5% of specimens and was not related to tumor site, stage, patient age or sex, or treatment modality. Overall and disease-free survival rates and response to induction chemotherapy did not differ significantly with respect to TATE. This study represents the first long-term, prospective evaluation of TATE and its prognostic significance in a single head and neck site. Contrary to the findings of earlier preliminary reports, our results suggest that TATE is not a clinical useful prognostic parameter in advanced laryngeal squamous cell carcinoma.
肿瘤相关组织嗜酸性粒细胞增多症（TATE）与上皮癌的预后相关，包括几个头颈部部位的癌症。本研究前瞻性地检查了248例III期和IV期喉鳞状细胞癌患者，以确定TATE的患病率及其潜在的预后意义。对治疗前的肿瘤标本进行组织病理学评估。分析TATE的存在和程度与其他肿瘤特征、患者特征及预后标准的关系。中位随访时间为48个月。在22.5%的标本中发现嗜酸性粒细胞增多，且与肿瘤部位、分期、患者年龄或性别以及治疗方式无关。总体生存率、无病生存率以及诱导化疗反应在TATE方面无显著差异。本研究是对TATE及其在单一头颈部部位预后意义的首次长期前瞻性评估。与早期初步报告的结果相反，我们的结果表明，TATE在晚期喉鳞状细胞癌中并非一个具有临床实用价值的预后参数。
