Weber F, Rieckmann P
Neurologische Universitätsklinik Göttingen.
Nervenarzt. 1995 Feb;66(2):150-5.
Multiple sclerosis (MS) is probably caused by multiple factors, but there is evidence that an autoimmunological process is relevant for the pathogenesis. Cytokines can operate in different ways in MS and the animal model "experimental allergic encephalomyelitis (EAE). "Interferon gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), TNF-beta, interleukin-1 (IL-1) and IL-2 are important inflammation mediators within the MS plaque, whereas IFN-alpha, IFN-beta, transforming-growth-factor-beta (TGF-beta) and IL-10 exert mainly immunosuppressive functions. Application of these anti-inflammatory cytokines and the selective block of pro-inflammatory cytokines are promising new therapeutic strategies with fewer side effects than the commonly used cytostatic drugs.
多发性硬化症（MS）可能由多种因素引起，但有证据表明自身免疫过程与发病机制相关。细胞因子在MS和动物模型“实验性变应性脑脊髓炎（EAE）”中可通过不同方式发挥作用。γ干扰素（IFN-γ）、肿瘤坏死因子-α（TNF-α）、TNF-β、白细胞介素-1（IL-1）和IL-2是MS斑块内重要的炎症介质，而α干扰素、β干扰素、转化生长因子-β（TGF-β）和IL-10主要发挥免疫抑制功能。应用这些抗炎细胞因子以及选择性阻断促炎细胞因子是有前景的新治疗策略，其副作用比常用的细胞毒性药物更少。
