Flachenecker P, Hartung H P
Klinische Forschungsgruppe für Multiple Sklerose, Julius-Maximilians-Universität Würzburg.
Nervenarzt. 1995 Feb;66(2):97-104.
This work summarizes the design and state of recruitment of the European multicentre prospective PRIMS (PRegnancy In Multiple Sclerosis) project on the relationship between pregnancy and multiple sclerosis. Relapse rate, long-term effects, influence of delivery and breastfeeding as well as immunomodulation during pregnancy and puerperium are reviewed. The results suggest an increase in relapse rate during the first 3 months of puerperium with an equal or lessened risk during the 9 months of pregnancy. Overall, long-term disability seems not to be increased. The mode of delivery or breast-feeding has no adverse effects on the course of the disease. Immunological phenomena during pregnancy do not correlate to the altered course of MS.
这项工作总结了欧洲多中心前瞻性PRIMS（多发性硬化症妊娠）项目关于妊娠与多发性硬化症之间关系的设计和招募情况。回顾了复发率、长期影响、分娩和母乳喂养的影响以及妊娠和产褥期的免疫调节。结果表明，产褥期前3个月复发率增加，而妊娠9个月期间风险相等或降低。总体而言，长期残疾似乎没有增加。分娩方式或母乳喂养对疾病进程没有不利影响。妊娠期间的免疫现象与MS病程改变无关。
