Kang M, Yoshimatsu H, Oohara A, Kurokawa M, Ogawa R, Sakata T
Department of Internal Medicine I, School of Medicine, Oita Medical University, Japan.
Physiol Behav. 1995 Feb;57(2):393-6. doi: 10.1016/0031-9384(94)00231-s.
Effects of ginsenoside Rg1 (Rg1), a major component of panax ginseng, on changes in ingestive behavior and rectal temperature induced by interleukin-1 beta (IL-1 beta) were investigated in rats. Intraperitoneal (ip) injection of IL-1 beta suppressed food and water intake and elevated rectal temperature. The suppressive effect of IL-1 beta on water intake was converted to an increase when 4.0 mM Rg1 was continuously infused into the third cerebroventricle (ICV) at a rate of 0.966 microliters/h. The elevation of rectal temperature induced by IL-1 beta was attenuated by ICV infusion of Rg1. The feeding suppression caused by IL-1 beta was unaffected by ICV infusion of Rg1. These results suggest that sustained ICV infusion of Rg1 may modulate the effects of IL-1 beta on ingestive behaviors, i.e., increase in water intake and sustained decrease in food intake, resulting in a lowering of body temperature.
研究了人参主要成分人参皂苷Rg1（Rg1）对白细胞介素-1β（IL-1β）诱导的大鼠摄食行为变化和直肠温度的影响。腹腔注射IL-1β可抑制食物和水的摄入，并使直肠温度升高。当以0.966微升/小时的速率将4.0 mM Rg1持续注入第三脑室（ICV）时，IL-1β对水摄入的抑制作用转变为增加。ICV注入Rg1可减弱IL-1β诱导的直肠温度升高。ICV注入Rg1对IL-1β引起的摄食抑制没有影响。这些结果表明，持续ICV注入Rg1可能调节IL-1β对摄食行为的影响，即增加水摄入和持续减少食物摄入，从而导致体温降低。
