Yoshimatsu H, Sakata T, Machidori H, Fujimoto K, Yamatodani A, Wada H
First Department of Internal Medicine, Faculty of Medicine, Kyushu University Fukuoka, Japan.
Physiol Behav. 1993 Jan;53(1):1-4. doi: 10.1016/0031-9384(93)90002-w.
Effects of ginsenoside Rg1 (Rg1) on histaminergic modulation of both adaptive behavior and thermoregulation were investigated at high ambient temperature. Continuous infusion of Rg1 using an osmotic minipump into the rat third cerebroventricle attenuated anorexia induced by elevation of ambient temperature from 21 degrees C to 31 degrees C. Intraperitoneal injection of alpha-fluoromethylhistidine (FMH), a specific suicide inhibitor of a histamine synthesizing decarboxylase enzyme, also prevented the anorexia induced by elevated temperature. The ratio of water intake to food intake, which showed no change on the first day after elevation of room temperature, was not influenced by treatment of either FMH or Rg1. Rectal temperature, which was normally maintained at a constant level even after shifting ambient temperature from 21 degrees C to 31 degrees C, elevated after FMH treatment. The Rg1 infusion, however, maintained rectal temperature normally at 31 degrees C. Hypothalamic histamine content increased in response to elevation of ambient temperature. The Rg1 infusion maintained constant histamine level against elevation of environmental temperature. Under the heated condition FMH reduced hypothalamic histamine. These findings suggest that Rg1 may modulate rat adaptive behavior by blockade of temperature-related information into the hypothalamic histamine neurons.
在高环境温度下，研究了人参皂苷Rg1（Rg1）对适应性行为和体温调节的组胺能调节作用。使用渗透微型泵将Rg1持续输注到大鼠第三脑室，可减轻环境温度从21摄氏度升高到31摄氏度所诱导的厌食症。腹腔注射α-氟甲基组氨酸（FMH），一种组胺合成脱羧酶的特异性自杀抑制剂，也可预防高温诱导的厌食症。室温升高后第一天水摄入量与食物摄入量的比值没有变化，FMH或Rg1处理均未对其产生影响。即使环境温度从21摄氏度转变为31摄氏度后，直肠温度通常也能维持在恒定水平，但FMH处理后直肠温度升高。然而，输注Rg1可使直肠温度在31摄氏度时正常维持。下丘脑组胺含量会随着环境温度的升高而增加。输注Rg1可使组胺水平在环境温度升高时保持恒定。在加热条件下，FMH会降低下丘脑组胺含量。这些发现表明，Rg1可能通过阻断温度相关信息传入下丘脑组胺能神经元来调节大鼠的适应性行为。
