Silva D C, de Oliveira Filho R S, Bevilacqua R G, Falzoni R, Birolini D
Serviço de Cirurgia Geral Eletiva, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo.
Rev Hosp Clin Fac Med Sao Paulo. 1994 Sep-Oct;49(5):217-20.
A case of a male patient, 66 years old, who exhibited in a period of six years many multicentric and multifocal synchronic and metachronic myxoid liposarcomas is reported. The authors made a revision of cytogenetics and DNA alterations recently identified in this type of tumor. The chromosomic alterations are represented by the translocation t(12;16) (q13;p11) and trisomy of the chromosome 8. The genic analysis revealed the presence of altered restriction fragments due to highly specific and reproducible methylation differences. In conclusion the authors suggest that the presence of the multiple tumors of this type in the same patient could be due to a common etiologic factor, not yet known, as being the initiator of this systemic illness of the fat tissue.
报告了一例66岁男性患者，其在六年期间出现了许多多中心、多灶性同时性和异时性黏液样脂肪肉瘤。作者对最近在这类肿瘤中发现的细胞遗传学和DNA改变进行了回顾。染色体改变表现为t(12;16)(q13;p11)易位和8号染色体三体。基因分析显示，由于高度特异性和可重复性的甲基化差异，存在限制性片段改变。总之，作者认为同一患者出现这种类型的多个肿瘤可能是由于一个尚未知晓的共同病因，它是这种脂肪组织全身性疾病的起始因素。
