Kaska W C, Carrano C, Michalowski J, Jackson J, Levinson W
Bioinorg Chem. 1978;8(3):225-36. doi: 10.1016/s0006-3061(00)80198-2.
Several thiosemicarbazone-metal complexes inhibit the RNA dependent DNA polymerase and the transforming ability of Rous sarcoma virus. Some complexes are equally as active as the free ligand whereas the activity of others is greatly enhanced. The 2-formyl pyridine thiosemicarbazone copper (II) complex is the most potent compound of this class that we tested. Some copper complexes of salicylaldehyde derivatives are very active also, particularly N-n-butyl, N-n-hexyl and N-benzylsalicylaldimine; no nickel complex of any salicylaldehyde compound is active. In addition, other metal ligands, such as dithizone, diacetyl bis (mercaptoethylimine), N-butyl thiocarbamate, 0,0' dimethyl dithiophosphate, potassium dithiooxalate, and cis-PtII(NH3)2Cl2 were tested with varying results.
几种硫代氨基脲金属配合物可抑制依赖RNA的DNA聚合酶以及劳氏肉瘤病毒的转化能力。一些配合物的活性与游离配体相当，而其他一些配合物的活性则大大增强。2-甲酰基吡啶硫代氨基脲铜（II）配合物是我们测试的这类化合物中最有效的。水杨醛衍生物的一些铜配合物也非常活跃，特别是N-正丁基、N-正己基和N-苄基水杨醛亚胺；任何水杨醛化合物的镍配合物都没有活性。此外，还测试了其他金属配体，如双硫腙、二乙酰双（巯基乙亚胺）、N-丁基硫代氨基甲酸盐、0,0'-二甲基二硫代磷酸酯、二硫代草酸钾和顺式-PtII(NH3)2Cl2，结果各不相同。
