Levinson W, Rohde W, Mikelens P, Jackson J, Antony A, Ramakrishnan T
Ann N Y Acad Sci. 1977 Mar 4;284:525-32. doi: 10.1111/j.1749-6632.1977.tb21985.x.
We have shown that three types of copper-binding ligands, thiosemicarbazones, 8-hydroxyquinolines, and isonicotinic acid hydrazide and their copper complexes, inactivate the transforming ability of RSV and inhibit its RNA-dependent DNA polymerases. Three other compounds, 2-pyridine thiosemicarbazone, 1-formyl isoquinoline thiosemicarbazone, and diphenyl thiocarbazone inhibit transformation by RSV intracellularly. Most but not all of these compounds bind to nucleic acids in the presence of copper, which may be important in their mode of action.
我们已经表明，三种类型的铜结合配体，即硫代氨基脲、8-羟基喹啉、异烟酸酰肼及其铜配合物，可使劳斯肉瘤病毒（RSV）的转化能力失活，并抑制其RNA依赖性DNA聚合酶。另外三种化合物，2-吡啶硫代氨基脲、1-甲酰基异喹啉硫代氨基脲和二苯基硫代卡巴腙在细胞内抑制RSV的转化。这些化合物中的大多数（但不是全部）在有铜存在的情况下与核酸结合，这可能对它们的作用方式很重要。
