Nüsing R M, Klein T, Siegle I, Brugger R, Ullrich V
Faculty of Biology, University of Konstanz, FRG.
Agents Actions Suppl. 1995;45:1-10. doi: 10.1007/978-3-0348-7346-8_1.
Thromboxane A2 and prostacyclin are the two prostanoids involved in the regulation of the vascular tone. Their release is controlled by the activity of cyclooxygenase which has made this enzyme a preferred pharmacological target. We here report on the distribution of the two isoforms of cyclooxygenase in cultured mesangial cells and on a selective inhibitor of the cytokine-inducible cyclooxygenase-2. We also comment on the structure of thromboxane and prostacyclin synthase and their regulation under physiological and pathophysiological conditions.
