Watry D, Lane T E, Streb M, Fox H S
Department of Neuropharmacology, Scipps Research Institute, La Jolla, California 92037, USA.
Am J Pathol. 1995 Apr;146(4):914-23.
The central nervous system (CNS) is a target for human immunodeficiency virus infection, and, in individuals with acquired immune deficiency syndrome, this can lead to a devastating dementia. Only certain viral variants appear capable of invading the CNS and infecting microglia and brain macrophages. To determine whether the virus entering the brain may be particularly pathogenic to the CNS, we isolated microglia from the brains of simian immunodeficiency virus-infected rhesus monkeys. Serial transfer of these cells into naive animals indicated that productive simian immunodeficiency virus infection could indeed be transferred. Furthermore, CNS infection occurred within a relatively short time span and was associated with viral gene expression in the brain and pathology characteristic of human immunodeficiency virus encephalitis. While demonstrating that neuropathogenic variants partition into the CNS, our approach will allow the dissection of functional neuropathogenic elements present in these viruses.
中枢神经系统（CNS）是人类免疫缺陷病毒感染的一个靶点，在获得性免疫缺陷综合征患者中，这可能导致严重的痴呆。只有某些病毒变体似乎能够侵入中枢神经系统并感染小胶质细胞和脑巨噬细胞。为了确定进入大脑的病毒是否对中枢神经系统具有特别的致病性，我们从感染了猿猴免疫缺陷病毒的恒河猴大脑中分离出小胶质细胞。将这些细胞连续转移到未感染的动物体内表明，猿猴免疫缺陷病毒的有效感染确实可以转移。此外，中枢神经系统感染在相对较短的时间内发生，并且与大脑中的病毒基因表达以及人类免疫缺陷病毒脑炎的病理特征相关。虽然证明了神经致病性变体在中枢神经系统中分布，但我们的方法将有助于剖析这些病毒中存在的功能性神经致病元件。
