咪达唑仑术前用药对阿芬太尼-氧化亚氮麻醉期间内隐记忆激活的影响。
The effect of midazolam premedication on implicit memory activation during alfentanil-nitrous oxide anaesthesia.
作者信息
De Roode A, Jelicic M, Bonke B, Bovill J G
机构信息
Department of Anaesthesiology, University Hospital of Leiden, The Netherlands.
出版信息
Anaesthesia. 1995 Mar;50(3):191-4. doi: 10.1111/j.1365-2044.1995.tb04553.x.
Eighty-three patients were given midazolam 0.1 mg.kg-1 by intramuscular injection as premedication before general anaesthesia with alfentanil-nitrous oxide. During anaesthesia patients were presented (through headphones) with either statements about common facts of some years ago (group A) (n = 43) or new verbal associations, e.g. names of fictitious, nonfamous people (group B) (n = 40). In a previous study with the same anaesthetic technique, but without premedication there was significant activation of implicit memory (p < 0.001). In this study we found no explicit or implicit memory for the auditory information presented during anaesthesia. Midazolam premedication can prevent implicit memory activation during alfentanil-nitrous oxide anaesthesia.
83例患者在使用阿芬太尼-氧化亚氮进行全身麻醉前，通过肌肉注射给予咪达唑仑0.1mg·kg-1作为术前用药。麻醉期间，通过耳机向患者呈现关于若干年前常见事实的陈述（A组）（n = 43）或新的语言联想，例如虚构的、不出名的人物名字（B组）（n = 40）。在之前一项采用相同麻醉技术但未进行术前用药的研究中，发现存在显著的内隐记忆激活（p < 0.001）。在本研究中，我们未发现对麻醉期间呈现的听觉信息存在外显或内隐记忆。咪达唑仑术前用药可预防阿芬太尼-氧化亚氮麻醉期间的内隐记忆激活。
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