Shield J P, Baum J D
Institute of Child Health, Bristol.
Arch Dis Child. 1995 Jan;72(1):56-7. doi: 10.1136/adc.72.1.56.
A 13 year old girl who had had transient neonatal diabetes developed permanent diabetes. She had raised fasting insulin concentrations suggestive of insulin resistance with a suboptimal insulin response to glucose loading. Both her mother and sister had profound insulin resistance; neither had clinical diabetes. This is the first time inherited insulin resistance has been implicated in the pathogenesis of permanent diabetes developing after transient neonatal diabetes.
一名曾患短暂性新生儿糖尿病的13岁女孩发展为永久性糖尿病。她空腹胰岛素浓度升高，提示存在胰岛素抵抗，对葡萄糖负荷的胰岛素反应欠佳。她的母亲和姐姐都有严重的胰岛素抵抗，但均无临床糖尿病。这是首次有研究表明遗传性胰岛素抵抗与短暂性新生儿糖尿病后发生的永久性糖尿病的发病机制有关。
