De Monte F
Department of Neurosurgery, University of Texas M.D. Anderson Cancer Center, Houston, USA.
Oncology (Williston Park). 1995 Jan;9(1):83-91, 96; discussion 96, 99-101.
Although generally benign tumors, meningiomas can cause serious neurological injury and, at times, vexatious management difficulties. Currently, the accepted management of these tumors is attempted total surgical excision when technically possible and associated with an acceptable risk. However, even with innovations in instrumentation and refinements in surgical technique, the goal of total resection may not be achievable. For these patients, and for those with recurrent tumors, options for treatment include reoperation, radiation therapy, and chemotherapy. Recent developments in surgical technique and instrumentation, radiosurgery, and brachytherapy have increased the treatment options, while clinical trials with tamoxifen and mifepristone (RU486) are adding information on the effectiveness of these drugs as chemotherapeutic agents. While the search continues for a uniformly successful management plan, physicians must be aware of the available options and try to help the patient decide which treatment is appropriate, based on current medical knowledge.
虽然脑膜瘤通常是良性肿瘤，但它可导致严重的神经损伤，有时还会带来棘手的治疗难题。目前，对于这些肿瘤，公认的治疗方法是在技术可行且风险可接受的情况下尝试进行全切除手术。然而，即便有器械方面的创新以及手术技术的改进，全切除的目标仍可能无法实现。对于这些患者以及复发肿瘤患者，治疗选择包括再次手术、放射治疗和化疗。手术技术与器械、放射外科和近距离放射治疗方面的最新进展增加了治疗选择，而他莫昔芬和米非司酮（RU486）的临床试验也在补充这些药物作为化疗药物有效性的信息。在继续寻找统一成功的治疗方案时，医生必须了解现有的选择，并基于当前医学知识，努力帮助患者决定哪种治疗方法合适。
