Smeele L E, van der Wal J E, van Diest P J, van der Waal I, Snow G B
Department of Oral and Maxillofacial Surgery and Oral Pathology, Free University Hospital, Amsterdam, The Netherlands.
Eur J Cancer B Oral Oncol. 1994 Nov;30B(6):374-6. doi: 10.1016/0964-1955(94)90014-0.
14 patients with an osteosarcoma of the craniofacial bones were evaluated retrospectively. 10 patients were males and 4 were females, ages varied from 10 to 74 years with a mean of 37 years. Ten tumours were located in the maxilla and four in the mandible. All patients underwent surgical resection of the tumour. One patient was irradiated postoperatively with 67.5 Gy and another patient received adjuvant chemotherapy with melphelan. Follow-up ranged from 6 months to 10 years with a mean of 4 years 2 months. Of 14 patients, 5 have died of local disease of whom 1 also had distant metastasis. Disease-free survival was 82.5% after 2 years and 68.8% after 5 years. Overall survival was 79.1% after 5 years. Univariate statistical analysis was carried out, revealing age < 35 years (P = 0.033) and radical surgery (P = 0.007) as statistically significant factors in disease-free survival. It is concluded that radical surgery in young patients with a craniofacial osteosarcoma gives long-term disease-free survival.
对14例颅面骨骨肉瘤患者进行了回顾性评估。10例为男性，4例为女性，年龄从10岁至74岁不等，平均年龄为37岁。10例肿瘤位于上颌骨，4例位于下颌骨。所有患者均接受了肿瘤手术切除。1例患者术后接受了67.5 Gy的放疗，另1例患者接受了美法仑辅助化疗。随访时间从6个月至10年不等，平均为4年2个月。14例患者中，5例死于局部疾病，其中1例还伴有远处转移。2年后无病生存率为82.5%，5年后为68.8%。5年后总生存率为79.1%。进行了单因素统计分析，结果显示年龄<35岁（P = 0.033）和根治性手术（P = 0.007）是无病生存的统计学显著因素。结论是，年轻的颅面骨肉瘤患者进行根治性手术可实现长期无病生存。
