Clark J L, Unni K K, Dahlin D C, Devine K D
Cancer. 1983 Jun 15;51(12):2311-6. doi: 10.1002/1097-0142(19830615)51:12<2311::aid-cncr2820511224>3.0.co;2-z.
The records of 66 patients with osteosarcoma of the jaw were reviewed. The ages of the 42 males and 24 females ranged from 12 to 79 years (mean, 34.2 years). Swelling and pain, the most frequent presenting complaints, were noted an average of three months before the patient was seen by a physician. Fifty-one percent of the lesions involved the maxilla and 49% involved the mandible. The most common sites of involvement were the body of the mandible and the alveolar ridge of the maxilla. Radiologically, most of the lesions in the maxilla were osteoblastic (50%), whereas most of those in the mandible were osteolytic (43%). Chondroblastic osteosarcoma was the most frequent histologic type (48%) and was associated with the best survival rate (47%). Treatment included radical and local surgery with radiotherapy, chemotherapy, or various combinations. The recurrence rate for all treatment modalities was 70%. Patients treated by initial radical surgery had the best survival (80%). Survival decreased to 27% with local surgery. Of the 43 (65%) patients who died, most died with uncontrolled local disease; only four patients had documented distant metastasis, which involved lung, cervical lymph nodes, spinal column, and brain.
回顾了66例颌骨骨肉瘤患者的病历。42例男性和24例女性的年龄范围为12至79岁（平均34.2岁）。肿胀和疼痛是最常见的就诊主诉，平均在患者就医前三个月出现。51%的病变累及上颌骨，49%累及下颌骨。最常见的受累部位是下颌骨体和上颌牙槽嵴。放射学上，上颌骨的大多数病变为成骨型（50%），而下颌骨的大多数病变为溶骨型（43%）。软骨母细胞性骨肉瘤是最常见的组织学类型（48%），且生存率最佳（47%）。治疗包括根治性和局部手术联合放疗、化疗或各种组合。所有治疗方式的复发率为70%。接受初始根治性手术治疗的患者生存率最佳（80%）。局部手术的生存率降至27%。在死亡的43例（65%）患者中，大多数死于局部疾病未得到控制；只有4例患者有记录的远处转移，累及肺、颈部淋巴结、脊柱和脑。
