Coleman-Mesches K, McGaugh J L
Center for the Neurobiology of Learning and Memory, University of California, Irvine 92717-3800, USA.
Brain Res. 1995 Jan 23;670(1):75-81. doi: 10.1016/0006-8993(94)01272-j.
The present study investigated possible lateralization of amygdala involvement in memory for aversively motivated training. Rats with bilateral cannulae aimed at the amygdalae were trained in a one-trial inhibitory avoidance task. Twenty-four h or 10 days later, animals received bilateral pre-test microinjections of either vehicle, 2% lidocaine, or unilateral infusions of each simultaneously. Five min after the infusions, retention was tested. Retention latencies of rats given bilateral lidocaine or unilateral lidocaine into only the right amygdala were significantly lower than controls. These results suggest that the right and left amygdalae may make differential contributions to the expression of memory, and that the contribution of the right amygdala may be more important to the expression of memory for aversively motivated training.
本研究调查了杏仁核参与厌恶性动机训练记忆时可能存在的功能侧化。将双侧套管对准杏仁核的大鼠进行单次试验抑制性回避任务训练。24小时或10天后，动物接受双侧预测试微量注射生理盐水、2%利多卡因，或同时单侧注射每种药物。注射后5分钟，测试记忆保持情况。双侧注射利多卡因或仅右侧杏仁核单侧注射利多卡因的大鼠的记忆保持潜伏期显著低于对照组。这些结果表明，左右杏仁核可能对记忆的表达有不同的贡献，并且右侧杏仁核对厌恶性动机训练记忆的表达可能更重要。
