Coleman-Mesches K, McGaugh J L
Center for the Neurobiology of Learning and Memory, University of California, Irvine 92717-3800, USA.
Behav Neurosci. 1995 Aug;109(4):642-7. doi: 10.1037//0735-7044.109.4.642.
Rats with bilateral cannulas aimed at the amygdalae received bilateral infusions of either buffer or lidocaine hydrochloride, or unilateral infusions of each, 5 min before continuous multiple-trial inhibitory avoidance (CMIA) training. Retention was tested 48 hr later. Some of the rats were retrained at this time and tested again 48 hr later. Bilateral infusions of lidocaine prior to the initial training impaired acquisition, retention, and relearning of the CMIA task. Unilateral infusions of lidocaine into the right or left amygdala did not affect acquisition. Rats given lidocaine into the right amygdala were impaired on retention 48 hr later. The findings are consistent with others indicating involvement of the amygdala in acquisition and consolidation of aversively motivated learning and suggest possible differential involvement of the right and left amygdalae in memory consolidation.
在双侧套管指向杏仁核的大鼠中，在连续多次试验抑制性回避（CMIA）训练前5分钟，给它们双侧注射缓冲液或盐酸利多卡因，或者单侧注射其中一种。48小时后测试记忆保持情况。此时，一些大鼠进行重新训练，并在48小时后再次测试。初始训练前双侧注射利多卡因会损害CMIA任务的习得、记忆保持和重新学习。单侧向右或左侧杏仁核注射利多卡因不影响习得。右侧杏仁核注射利多卡因的大鼠在48小时后的记忆保持受损。这些发现与其他表明杏仁核参与厌恶性动机学习的习得和巩固的研究结果一致，并表明左右杏仁核在记忆巩固中可能存在不同程度的参与。
