Parent M B, Avila E, McGaugh J L
Department of Psychobiology, University of California, Irvine, USA.
Brain Res. 1995 Apr 10;676(2):235-44. doi: 10.1016/0006-8993(95)00095-8.
We previously reported that increased training in an escape task partially attenuates the memory impairment produced by large amygdala lesions induced 1 week following training. The present study examined the effect of amount of preoperative training on the retention of rats with lesions restricted to the amygdala basolateral complex. Rats received 1 or 10 training trials in a footshock-motivated escape task and 1 week later sham lesions or neurotoxic lesions of the basolateral complex. Four days after recovery from the surgery they were tested for inhibitory avoidance retention and then 2 days later given continuous multiple trial inhibitory avoidance training (CMIA) in the same apparatus. The basolateral complex lesions significantly decreased the retention latencies of rats given 1 or 10 trials. However, following administration of footshock on the CMIA task, the performance of the lesioned rats reflected the degree of preoperative escape training. The basolateral complex lesions also increased open field locomotor activity, an effect that may have contributed to the shorter retention latencies in lesioned animals. These findings indicate that an intact amygdala basolateral complex is not critical for the retention of the escape training.
我们之前报道过，在一项逃避任务中增加训练，可部分减轻在训练1周后诱导产生的大杏仁核损伤所导致的记忆损伤。本研究考察了术前训练量对杏仁核基底外侧复合体局限损伤大鼠记忆保持的影响。大鼠在足部电击驱动的逃避任务中接受1次或10次训练试验，1周后接受基底外侧复合体的假损伤或神经毒性损伤。术后恢复4天后，对它们进行抑制性回避记忆测试，然后在2天后于同一装置中给予连续多次试验的抑制性回避训练（CMIA）。基底外侧复合体损伤显著缩短了接受1次或10次试验大鼠的记忆保持潜伏期。然而，在CMIA任务中给予足部电击后，损伤大鼠的表现反映了术前逃避训练的程度。基底外侧复合体损伤还增加了旷场运动活动，这一效应可能导致了损伤动物记忆保持潜伏期较短。这些发现表明，完整的杏仁核基底外侧复合体对逃避训练的记忆保持并非至关重要。
