Estevão M H, Barosa L M, Matos L M, Barroso A A, da Mota H C
Hospital Pediátrico de Coimbra, Portugal.
Eur J Pediatr. 1995 Feb;154(2):120-2. doi: 10.1007/BF01991914.
Neurobrucellosis is an uncommon disease in children. The authors present two cases of brucellar meningo-encephalitis. Headache and vomiting were the main complaints and one child had also some behavioural disturbance as well as papilloedema and sixth cranial nerve palsy. The clinical diagnosis was suggested by epidemiological data in both cases. Blood and CSF cultures confirmed brucellar aetiology in one of the cases and positive serum and CSF specific antibodies in both. Clinical course was favourable after treatment with doxycycline, rifampicin and streptomycin. No relapse occurred and there were no sequelae.
Neurobrucellosis should be considered in the differential diagnosis of neurobehavioural disturbance of children living in areas where brucellosis is endemic.
神经型布鲁氏菌病在儿童中是一种罕见疾病。作者报告了两例布鲁氏菌性脑膜脑炎病例。主要症状为头痛和呕吐,其中一名儿童还伴有行为障碍、视乳头水肿和第六对脑神经麻痹。两例病例均根据流行病学资料做出临床诊断。血培养和脑脊液培养在其中一例中证实为布鲁氏菌病因,两例血清和脑脊液特异性抗体均呈阳性。经强力霉素、利福平及链霉素治疗后临床病程良好。未出现复发,也无后遗症。
对于生活在布鲁氏菌病流行地区的儿童出现的神经行为障碍进行鉴别诊断时,应考虑神经型布鲁氏菌病。