Oikkonen M, Kärkelä J, Seppälä T
Department of Anaesthesia, Tampere University Hospital, Helsinki, Finland.
Eur J Clin Pharmacol. 1995;47(5):445-7. doi: 10.1007/BF00196859.
Single concurrent plasma and lumbar spinal fluid samples were collected from twenty-two patients given IV dixyrazine 0.15 mg/kg, 10-106 min earlier in an open study. Dixyrazine penetrated rapidly into the spinal fluid; the CSF/P ratio was 0.3 by 10 min after drug administration and persisted at that level during the study period. The uncontrolled sedative and anxiolytic effects assessed by the patients were slight, and were correlated with the CSF drug concentrations only during the first 30 min after medication.
在一项开放性研究中，于给药前10 - 106分钟从22例接受静脉注射0.15mg/kg二乙嗪的患者身上同时采集血浆和腰椎脑脊液样本。二乙嗪迅速渗透入脑脊液；给药后10分钟时脑脊液/血浆比值为0.3，且在研究期间维持该水平。患者评估的未受控制的镇静和抗焦虑作用轻微，且仅在用药后的前30分钟内与脑脊液药物浓度相关。
