Kivalo I, Rosenberg P
Ann Chir Gynaecol. 1976;65(4):28n-9.
A double-blind controlled study based on 197 women undergoing legal abortion (part I) or gynaecological surgery (part II) was employed to estimate the antiemetic effect of dixyrazine. Dixyrazine or part I) or intramuscularly at the end of anaesthesia (part II) and repeated when necessary. The follow-up period lasted 12 and 18 hours, respectively. Overall, a marked antiemetic response in the dixyrazine groups was observed when compared with the placebo treated groups in both part I and II (p less than 0.001). Dixyrazine proved to be superior to placebo especially in patients who were not prone to nausea or who received no major postoperative analgesics (p less than 0.001).
一项基于197名接受合法堕胎（第一部分）或妇科手术（第二部分）的女性的双盲对照研究，用于评估地西拉嗪的止吐效果。地西拉嗪在第一部分于术前30分钟静脉注射，或在第二部分于麻醉结束时肌肉注射，并在必要时重复给药。随访期分别持续12小时和18小时。总体而言，在第一部分和第二部分中，与安慰剂治疗组相比，地西拉嗪组均观察到明显的止吐反应（p<0.001）。地西拉嗪被证明优于安慰剂，尤其是在不易恶心或未接受主要术后镇痛药的患者中（p<0.001）。
