Oikkonen M, Heine H, Salminen U, Romppanen O, Inberg P
Department of Anaesthesia, Tampere University Hospital, Finland.
Acta Anaesthesiol Scand. 1994 Apr;38(3):214-7. doi: 10.1111/j.1399-6576.1994.tb03876.x.
Peroral dixyrazine (15-30 mg, n = 50) and diazepam (4-10 mg, n = 50) were used as premedicants for geriatric patients having cataract surgery under regional block. Compared to the diazepam patients, a larger number of the dixyrazine medicated patients appeared anxious, and there was a statistically significant difference between the groups, when summing up changes in anxiety throughout the study period. The dixyrazine patients needed more frequent supplementation with intravenous sedative drugs, compared with their diazepam counterparts. Peroral dixyrazine is an applicable choice for calm patients, when only slight sedation, or avoidance of somnolence are required.
口服地昔帕明（15 - 30毫克，n = 50）和地西泮（4 - 10毫克，n = 50）被用作在区域阻滞下进行白内障手术的老年患者的术前用药。与地西泮组患者相比，使用地昔帕明的患者中出现焦虑的人数更多，在总结整个研究期间的焦虑变化时，两组之间存在统计学上的显著差异。与使用地西泮的患者相比，使用地昔帕明的患者需要更频繁地补充静脉镇静药物。当仅需要轻微镇静或避免嗜睡时，口服地昔帕明是安静患者的适用选择。
