5-羟色胺3受体在降钙素抗溃疡作用中的角色。

The role of 5-HT3 receptors in the anti-ulcer effect of calcitonin.

Erin N, Yeğen B C, Oktay S

Department of Physiology, Marmara University, School of Medicine, Haydarpaşa-Istanbul, Turkey.

Gen Pharmacol. 1994 Dec;25(8):1599-605. doi: 10.1016/0306-3623(94)90360-3.

Abstract

The aim of the present study was to determine the role of 5-HT3 receptors of the gastroprotective effect of salmon calcitonin (sCT) and sCT-induced changes in gastric, hepatic, brain and brainstem glutathione (GSH) and lipid-peroxidation (LP) levels in rats subjected to cold-immobilization stress. 2. Stress exposure resulted in ulcer formation and a decrease in GSH levels of the liver, brain and brainstem and an increase in gastric and hepatic LP (P < 0.05). 3. sCT prevented stress-induced gastric ulcer development (P < 0.01) and reversed the decrease in hepatic and brain GSH levels (P < 0.05). 4. In the present study, a 5-HT3 receptor antagonist, ICS 205,930 was used. Interestingly, the effect of the blocker on GSH and LP levels of the tissues studied was similar to those of sCT. 5. ICS 205,930 dose dependently reversed the anti-ulcer effect of sCT although it did not antagonize the effect of sCT on GSH and LP levels, but it seemed to show an additive interaction for brain and brainstem GSH and gastric LP levels with sCT.

摘要

本研究的目的是确定5-羟色胺3（5-HT3）受体在鲑鱼降钙素（sCT）胃保护作用中的作用，以及sCT诱导的冷束缚应激大鼠胃、肝、脑和脑干中谷胱甘肽（GSH）水平及脂质过氧化（LP）水平的变化。2. 应激暴露导致溃疡形成，肝脏、脑和脑干中GSH水平降低，胃和肝脏中LP增加（P < 0.05）。3. sCT可预防应激诱导的胃溃疡发展（P < 0.01），并逆转肝脏和脑中GSH水平的降低（P < 0.05）。4. 在本研究中，使用了5-HT3受体拮抗剂ICS 205,930。有趣的是，该阻滞剂对所研究组织的GSH和LP水平的影响与sCT相似。5. ICS 205,930剂量依赖性地逆转了sCT的抗溃疡作用，尽管它并未拮抗sCT对GSH和LP水平的影响，但它似乎与sCT在脑和脑干GSH及胃LP水平上表现出相加作用。