Shvartsman P Ia, Romashkina T B
Genetika. 1995 Feb;31(2):205-8.
The frequency of recessive sex-linked lethal mutations (RSLLM) induced in chromosome Muller-5 of mature sperms by treatment with ethyleneimine (EI) or methyl methanesulfonate (MMS) was shown to increase when male pronucleus or zygote was formed in the oocyte cytoplasm of the mutagen-sensitive line mus(2)201G1. The increase in the total number of mutations in the mutant cytoplasm was accompanied by a transformation of damages causing mosaic mutations into damage to the genome, which are recorded as complete mutations.
结果显示，在用乙撑亚胺（EI）或甲磺酸甲酯（MMS）处理后，成熟精子的Muller-5染色体中诱导产生的隐性性连锁致死突变（RSLLM）频率，在诱变敏感品系mus(2)201G1的卵母细胞细胞质中形成雄原核或合子时会增加。突变细胞质中突变总数的增加伴随着导致嵌合突变的损伤转变为对基因组的损伤，这些损伤被记录为完全突变。
