Liubimova I K, Abilev S K, Migachev G I
Genetika. 1995 Feb;31(2):268-72.
A comparative study of the mutagenic activity of 21 derivatives of biphenyl was performed in the strain TA1538 of Salmonella typhimurium. The position effect of carboxyl, amide, aldehyde, and ether groups was examined. The para position of substituents, among which at least one is a nitro group, causes mutagenic activity in most of the molecules studied. Derivatives of biphenyl that have no substituents in the para position were inactive. In addition, 4-nitrobiphenyl (4-NBP), 4-nitro-2'-carboxy biphenyl (4-N-2'-C-BP), 4,4'-dinitro-2'-carboxy biphenyl (4-4'-DN-2'-C-BP), and 4,4'-dinitro-2,2'-carboxy biphenyl (4-4'-DN-2,2'-DC-BP) induced no frameshift mutations in TA1538. The most active was 2,4,4'-TN-6-C-6'-Ad-BP, giving up to 800 revertants per nmol; 2,4,6,2'-TN-4'-6'-DC-BP and 2,4,2',4'-TN-2'-C-BP, which induced 250 and 350 revertants per nmol, respectively, were highly active frameshift mutagens.
在鼠伤寒沙门氏菌TA1538菌株中对21种联苯衍生物的诱变活性进行了比较研究。考察了羧基、酰胺基、醛基和醚基的位置效应。在大多数所研究的分子中，取代基的对位（其中至少有一个是硝基）会引起诱变活性。在对位没有取代基的联苯衍生物没有活性。此外，4-硝基联苯（4-NBP）、4-硝基-2'-羧基联苯（4-N-2'-C-BP）、4,4'-二硝基-2'-羧基联苯（4-4'-DN-2'-C-BP）和4,4'-二硝基-2,2'-二羧基联苯（4-4'-DN-2,2'-DC-BP）在TA1538中未诱导移码突变。活性最高的是2,4,4'-三硝基-6-羧基-6'-氨基联苯，每纳摩尔产生多达800个回复体；2,4,6,2'-三硝基-4'-6'-二羧基联苯和2,4,2',4'-三硝基-2'-羧基联苯分别每纳摩尔诱导250个和350个回复体，是高活性的移码诱变剂。
